Conversion from Set-Ratio Opioid/Acetaminophen, Opioid/Aspirin, or Opioid/Nonsteroidal Combination Medication When changing clients from preset ratio opioid/non-opioid drug regimens a call need to be built if to carry on the non-opioid analgesic. If a choice is created to discontinue using non-opioid analgesic, it might be needed to titrate the dos